Thursday, June 30, 2011

Chronic pain affects 116 MILLION Americans

Wow.

The report, mandated by the healthcare overhaul law, estimates that chronic pain costs between $560 billion and $635 billion each year in medical expenses and lost productivity.

I guess that's job security for me.

From the LA Times.

Why Paleo isn't working for you

  1. You're not eating Paleo. You're eating Faileo: processed meats, lean protein, canola oil, "Paleo pancakes" or "Paleo gluten-free banana bread."
  2. You haven't given it enough time.
  3. You're not sleeping enough or early enough or well enough.
  4. You are eating all muscle meat and no fatty organs.
  5. You've got some other health issue going on that can't be resolved 100% through diet: low-grade infection, systemic inflammation, some auto-immune component, whatever.
  6. You've truly spent too much time fucking up your metabolism and you can't heal it 100% now, no matter what you do. Sucks, doesn't it?
  7. Who knows, maybe it's just not right for you. Try something else and see what happens. If that works better for you, fuck Paleo. <-- this is what distinguishes us from the goddamn vegans who say that if your health gets worse on a vegan diet, you're "doing it wrong." No. Sometimes your health gets worse even if you do everything "right." Then it's time to try something else in practice, not beat yourself up for not being perfect in theory.

Monday, June 27, 2011

open letter on cholesterol

Dear XXXXX,

I promised you some info on cholesterol, fat, and heart disease. I apologize in advance for the large amount of information at once, which may be overwhelming, confusing, and perhaps unhelpful. (I actually trimmed this down from an even longer draft, if you can believe that.)

If you want to learn more, I'd be happy to send you more information. Please feel free to ask questions if you have any. Cholesterol is a very confusing substance and frankly, most medical doctors do not have a clue about it (in my humble and non-expert opinion).

Some of the links below to peer-reviewed journal articles may not work for you, since I have access to those articles through IU. If you want a copy of an article you can't access, just let me know.

Best regards,

Jae

Eating Cholesterol does not raise serum cholesterol -- the 1955 peer-reviewed article that demonstrated that increasing dietary intake of cholesterol has an insignificant impact on serum cholesterol in (adult male) humans. Humans self-manufacture the vast majority of the cholesterol they need. Why do the AHA, ADA, ACS all tell us to limit our cholesterol intake? It makes no sense. (The article was actually written by researchers who were trying to prove that eating cholesterol is harmful. When they discovered that it wasn't, they modified their hypothesis to say that eating fat, especially saturated fat, was harmful because it elevated serum cholesterol.)

"What if it's all been a big fat lie?" -- the NYT Magazine article by Gary Taubes, award-winning science journalist. Great summary article about major questions behind the idea that dietary fat causes heart disease.

The French Paradox: French people eat more saturated fat and yet have lower rates of heart disease.

The Israeli Paradox: Israelis eat a lot more polyunsaturated fat, which is supposedly healthy because it lowers serum cholesterol. But they have the highest heart disease rates in the region.

The Diet-Heart Hypothesis -- a great blog post dissecting the lipid hypothesis. The author, Stephan, has a PhD in neurobiology but his passion is nutrition, and his posts are always well thought-out. In the past, some people have told me that they don't take my claims seriously because I keep linking to this blog and not to peer-reviewed articles. I hope you can see that 1) he cites peer-reviewed articles in his blog and 2) the level of thinking he exhibits is far greater than what you see in typical peer-reviewed articles on nutrition science.

Subdividing Lipoproteins -- a blog post by the same guy, about research on saturated fat and its impact on cholesterol profiles. Sat fat seems to improve cholesterol overall. The surprising conclusion is that eating saturated fat is probably the best way to improve your cholesterol profile, in direct opposition to what the AHA suggests. Now, the French/Israeli paradoxes are starting to make more sense.

Most cardiac patients have low or normal LDL. Then why do doctors insist on measuring it and prescribing statins if LDL is high? The article's conclusion is that "well, our guidelines for LDL may be too high. We need to push the LDL guidelines even lower." I think this is completely wrong. LDL is not a good indicator of heart disease risk, period. This makes more sense in light of the blog post above regarding "Subdividing Lipoproteins."

Did you know that most blood tests don't even measure LDL? They calculate it through a (sometimes wildly inaccurate) formula.

Forty eight (!) studies demonstrating that in the elderly, higher cholesterol is associated with lower mortality. (The site is in Portuguese but the studies are summarized in English.) Okay, so lowering your cholesterol might lower your risk of heart disease (although I think not); but what's the good if it increases your risk of dying from cancer, Alzheimer's, and other chronic illnesses? Personally, I'd rather die of a heart attack than after a prolonged and painful fight with cancer. (For info on cholesterol and Alzheimer's see the bonus section at the bottom of this email.)

Women may not benefit from statins. From the always dubious TIME magazine (although they happened to get this mostly right, in my opinion): "Yet there is little evidence that [statins] prevent heart disease in women. In past research, statin therapy has been shown to prolong the lives of people with heart disease. It has also been shown to stave off the onset of heart disease in healthy at-risk adults. But researchers who have broken out and analyzed the data on healthy female patients in these trials found that the lifesaving benefit, which extends to men, does not cross the gender divide. What's more, there's evidence that women are more likely than men to suffer some of the drugs' serious side effects, which can include memory loss, muscle pain and diabetes."

A peer-reviewed study on women and statins:Drug Treatment of Hyperlipidemia in Women: "Conclusions  For women without cardiovascular disease, lipid lowering does not affect total or CHD mortality. Lipid lowering may reduce CHD events, but current evidence is insufficient to determine this conclusively. For women with known cardiovascular disease, treatment of hyperlipidemia is effective in reducing CHD events, CHD mortality, nonfatal myocardial infarction, and revascularization, but it does not affect total mortality."

Here's one that may be of particular interest to you: Japanese subjects with total cholesterol higher than 240 mg/dL have the lowest risk of overall mortality (PDF, 2.2 mb). Particularly interesting for you may be this sentence: "We suggest that Japanese subjects with cholesterol levels ≥ 240... should not be regarded as hypercholesterolemic or dyslipidemic except when having some genetic disorders like familial hypercholesterolemia because they are in the safest ranges in terms of all-cause mortality." How confident can we be that a TC of 250 or even 300 is pathological? Not very.

Coronary heart disease is extremely rare -- nearly unheard of -- in "primitive" populations that do not eat industrially produced foods (processed food, sugar, trans fats, industrially produced "vegetable" oils such as corn oil, soybean oil, canola oil). Links:

Ischemic Heart Attacks: Disease of Civilization
Masai and Atherosclerosis
The Kitavans: Wisdom from the Pacific Islands


If you really want to dig deeper into a reputable source who has done research on cholesterol, I'd recommend checking out Gary Taubes's Good Calories, Bad Calories. He also has a shorter book called Why We Get Fat, which presents the same ideas and more research, but in language that is easier to read. In these books, Taubes criticizes the conventional medical thinking on cholesterol, fat, obesity, and heart disease (loosely speaking, the "lipid hypothesis"). He also presents his own ideas about what is really going on: the carbohydrate hypothesis. I happen to think that the carbohydrate hypothesis is incorrect, or at least very incomplete. However, his criticisms of the lipid hypothesis (and the related "diet-heart hypothesis") are excellent.

------
In summary:

I think the idea that serum cholesterol causes heart disease is probably incorrect. Cholesterol is probably more like the firefighters who are dispatched to the fire. Elevated LDL is not a cause of heart disease. It is probably a marker of something else that has gone wrong in your body. The best hypotheses we have now are that it is a sign of inflammation or of oxidizative damage. LDL is your repair staff, not your body's attempt to kill you.

I think that statins are frankly dangerous and do more harm than good for the vast majority of people who take them, especially women who have never had a cardiac event.

If there is any marginal benefit of taking statins (for men), it is probably due to the statin's anti-inflammatory effect. You can get the same benefit (actually much  more) from avoiding inflammatory foods -- namely, industrially produced vegetable oils, trans fats, sugar, wheat. (I suppose wheat is more of an agricultural product than an industrial one. Still, it tends to be pro-inflammatory.) The traditional Masai do not take statins, and they subsist on a high-saturated-fat and high-cholesterol diet. Same goes for the traditional Inuit. And the Tokelau. And their rate of heart disease is near zero. And it's not just genetics, because when these people start eating more industrialized foods, they start getting heart disease just like us.

Please keep in mind I am not a medical professional and am not qualified to give medical advice. However, as a person of reasonable intelligence who has read a lot of research that most medical doctors have not, I think it is reasonable to question whether the current medical thinking on cholesterol and statins is wholly incorrect.

Some of the evidence presented here is rock-solid, while in others
it is more controversial (e.g., in the articles on dementia and suicide, below). If you look for confounding or contradictory evidence, you will find it, and I encourage you to do so.
My goal is not to show you that my ideas about cholesterol are correct, but rather to demonstrate that the evidence behind the demonization of fat/cholesterol is weak and inconclusive at best, not incontrovertible as the AHA, AMA, ACS, ADA and the other abbreviated agencies would have you believe.

-----
Bonus links: I almost didn't include this because this email is already too long, but it's important information:

Low serum cholesterol is linked with dementia in hundreds of studies, as well as with depression, suicide, violent behavior, and even increased risk of deaths from accidents. Your brain needs cholesterol to function properly. Taking statins to lower cholesterol may increase your risk of Alzheimer's as well as other unpleasant things. Links:

Depression: Association of low serum total cholesterol with major depression and suicide.

RESULTS: Low serum total cholesterol was associated with low mood and subsequently a heightened risk of hospital treatment due to major depressive disorder and of death from suicide. CONCLUSIONS: Our resultssuggest that low serum total cholesterol appears to be associated with low mood and thus to predict its serious consequences. 

Suicide: Low serum cholesterol in suicide attempters

Cholesterol concentrations in suicide attempters were found to be significantly lower compared with both psychiatric and normal controls, when sex, age, psychiatric diagnosis, and physical conditions (serum total protein and red blood cell count) were adjusted for. This significant relationship was observed in mood disorders and personality or neurotic disorders, but not in schizophrenia spectrum disorders. These results support the previous claim that lowercholesterol level is associated with an increased risk of suicidal behavior.

Violent behavior:
Cholesterol and violence: is there a connection? This one is especially interesting because the data include experimental studies (meant to establish causation rather than mere association).

DATA SYNTHESIS:

Observational studies (including cohort, case-control, and cross-sectional studies) consistently showed increased violent death and violent behaviors in persons with low cholesterol levels. Some meta-analyses of randomized trials found excess violent deaths in men without heart disease who were randomly assigned to receive cholesterol-lowering therapy. Experimental studies showed increased violent behaviors in monkeys assigned to low-cholesterol diets. Human and animal research indicates that low or lowered cholesterol levels may reduce central serotonin activity, which in turn is causally linked to violent behaviors. Many trials support a significant relation between low or lowered cholesterol levels and violence (P < 0.001).

CONCLUSIONS:

A significant association between low or lowered cholesterol levels and violence is found across many types of studies. Data on this association conform to Hill's criteria for a causal association. Concerns about increased risk for violent outcomes should figure in risk-benefit analyses for cholesterol screening and treatment.

Dementia and Alzheimer's: too many to wade through, but here's one article:

Twenty-six-year change in total cholesterol levels and incident dementia : The Honolulu-Asia aging Study

Results: Cholesterol levels in men with dementia and, in particular, those with Alzheimer disease had declined at least 15 years before the diagnosis and remained lower than cholesterol levels in men without dementia throughout that period. The difference in slopes was robust to adjustment for potential confounding factors, including vascular risk factors, weight change, alcohol intake, and use of lipid-lowering agents. Conclusion: A decline in serum total cholesterol levels may be associated with early stages in the development of dementia.

Sunday, June 26, 2011

sketches for how to think about fitness

1. Keith Norris's excellent graph on health vs fitness as an introduction to where most people are, where most people are interested in getting to, and where most fitness "trainers" doom their clients to hanging out. How most people want to maximize health with minimal effort, and they really don't understand how little effort it takes. 1-2 hrs a week is all it takes to get to the end of the easy gains. 1-2 hrs a week is all it takes to maintain that for life.

2. The Paleo template/heuristic as a useful way to start thinking about food. If it's wildly outside your evolutionary heritage, chances are it's not good for you. Paint this picture with examples from wild vs. zoo animals, then talk about zoo humans, then talk about exceptions.

3. Why I don't trust trainers and dieticians who talk a lot about macronutrients. Carbs are not carbs. Carbs from fruit != carbs from HFCS != from tubers != grains and legumes.

In fact, even among the grains, carbs from wheat != carbs from rice.

4. How mind-bogglingly complicated nutrition can be. High HDL is probably good except in certain cases where it may be indicative of inflammation. Omega-3 fish oil is great but it oxidizes easily. Excess fructose is harmful but fruit is probably okay unless you are already metabolically deranged.

5. Don't trust anyone who is very confident about vectors of causality.

6. Feel pretty good about #1 but the others need to be distilled down to basic principles.

7. I know more about cholesterol than your doctor does. And I know very little. That should scare you. Doctors never discuss:

High TC linked with lower overall mortality
Low LDL linked with large numbers of cardiac cases
Even among doctors who understand the need to screen for LDL profiles, they don't entertain the idea that small dense LDL may not be causative of heart disease but rather a marker of something else going wrong.

Wednesday, June 22, 2011

High-fat vs. Horrible-fat

Tom Naughton just skewered some "high-fat" studies done on mice and rats and came up with this very useful phrase:


A “Western” diet for rodents based on AIN-93G, providing 30% of fat from lard, 30% from butterfat, 30% from Crisco (hydrogenated vegetable oil), and for EFA, 7% from soybean oil and 3% from corn oil.  Approximate energy from fat 40%, carbohydrate 44%, protein 16%.

That’s not a high-fat diet by my standards — I probably get 60% of my calories from fat– but it’s certainly a high horrible-fat diet.  Of the fat calories, 40% come from hydrogenated oil, corn oil, and soybean oil.  In other words, oils that wouldn’t exist without the wonders of industrial extraction.

 (bolding is mine)

Emphasizing quality over quantity is one of the basic tenets of "the Paleo template" (another useful phrase, coined by Chris Kresser).

I've been thinking similar things about carbs (it's not high-carb diets that are harmful, it's the kind of carbs that matter) but Naughton's phrasing is exactly right.

Tuesday, June 21, 2011

Dan Gilbert: people are terrible at figuring out what makes them happy

From his TED talk:

if you were to go into a wine shop and you had to buy a bottle of wine, and you see them here for 8, 27 and 33 dollars, what would you do? Most people don't want the most expensive, they don't want the least expensive. So, they will opt for the item in the middle. If you're a smart retailer, then, you will put a very expensive item that nobody will ever buy on the shelf, because suddenly the 33-dollar wine doesn't look as expensive in comparison.
 So in price sheets we should put some outrageously expensive option for private training.

Another, bigger issue for a future blog:

The issue is that many people will screw up in figuring out their priorities in diet, training, etc. because they will underestimate the value of doing so for the future, and overestimate the value of eating that pizza or brownie today.

Bernoulli's gift, Bernoulli's little formula, allows us, it tells us how we should think in a world for which nature never designed us. That explains why we are so bad at using it, but it also explains why it is so terribly important that we become good, fast. We are the only species on this planet that has ever held its own fate in its hands. We have no significant predators, we're the masters of our physical environment; the things that normally cause species to become extinct are no longer any threat to us. The only thing -- the only thing -- that can destroy us and doom us are our own decisions. If we're not here in 10,000 years, it's going to be because we could not take advantage of the gift given to us by a young Dutch fellow in 1738, because we underestimated the odds of our future pains and overestimated the value of our present pleasures.

Just as ppl underestimate the odds of getting cancer in the future and overestimate the value of junk food today.

Thursday, June 16, 2011

Notes from Robert Cialdini's podcast on persuasion

Fascinating podcast with transcript available. Lots of great ideas for persuading people to join a gym, sign up for personal training, commit to a nutrition plan, whatever. 

6 basic principles:

1. reciprocity -- do something for them before you ask them to do something for you. Don't say "if you buy this, I'll donate 10% to a charity." Say "I've ALREADY given this money to charity -- now will you buy this for me?" The order is important.

Amplify the effect by personalizing the thing we give to that person. Not a generic gift to everybody.

Find ppl you can help out. Figure out what you can give them that is personalized.

Ben Franklin; ask your rival to lend you a book. As soon as they've done it, they say to themselves, I just lent a book to this guy. He's not so bad after all. When you return it, say "Thanks -- great book -- maybe we could talk about it sometime. Oh, and here's a book you'd like." They have to think "wait a minute, why would I go out of my way to help this person? He must not be so bad" and now you've created an opportunity that was previous a dead-end.

2. scarcity -- the iphone and the Wii for example. Great products, but the reason ppl lined up in sleeping bags in Nov was because of scarcity. scarcity can be a function of time -- for a limited time only! it can also be an issue of framing: real estate uses this all the time: this is the last house in the neighborhood, not gonna last long.

3. authority -- tell ppl why you're qualified

4. consistency -- ppl will try to be consistent with what they've said they'd do. Before delivering any recommendations: Get ppl to speak and to write down their priorities, their values, and their goals -- because people want to live up to what they write down. Super important for client intakes, especially for fat loss, adherence, compliance. Get them to write down what their goals, their priorities, and then match those priorities with a fitness/nutrition plan so they'll be more likely to succeed.

5. liking -- if they like you, they're more likely to say yes. 3 simple things to increase the rapport before we try to influence: 1. identify similarities. commonalities (hobbies, values, shared struggles). 2. give genuine praise where they deserve it. 3. identify opportunities for cooperative goals where we can work toward mutual purposes (work together on fat loss goals).

6. consensus. give them evidence that ppl just like them have been saying yes to it. ppl don't want to be outliers. ppl don't want to go against the wisdom of the crowds of ppl just like them that have already said yes. TESTIMONIALS are important. the more you can provide, the more similar the voices of those testimonials to the target market, the more effective. Prioritize the video testimonials from ppl who dress, talk, look like the ppl of your target audience.







Misc notes:
 
The one word that can increase sales 50%: "Because" -- ppl need REASONS for what they do. Study involving a copier "may I cut because I'm in a hurry?" 94% agreed. "Can I jump ahead to use the copier?" 63% said yes. "Can I use the copier b/c I need to make copies?" 93% said yes even though the sentence provides a nonsensical reason.


When people are UNCERTAIN, the three principles that are most potent:

scarcity
authority
consensus (social proof)


The moment of power: when someone says "Thank you," that is a moment of power offered to you. You don't say: "yes, now you owe me one." You say, "I was glad to do it. You'd have done the same for me." You frame that moment to empower you for a future moment. "Of course, it's what partners do for one another."


Notes from other Cialdini interviews: